This seminar will focus on research conducted in Dr. Vugmeyster’s group devoted to characterization of the intrinsic flexibility of amyloid fibrils spanned by amyloid-beta (1-40) peptide. Our goal is a quantitative description of internal dynamics guided by NMR data. We develop solid-state NMR geared toward deuterium nuclei, which are known to be very sensitive to dynamics processes. The analysis of the data obtained by the novel methodology is coupled to phenomenological modeling allowing for determination of the amplitudes of motions and rate constants over a wide range of temperatures. We thus obtain a detailed picture of motions in amyloid-beta fibrils of the wild-type peptide, as well as its naturally occurring mutants and aggressive post-translational modifications that are known to enhance aggregation.
Prof. Dr. Björn Corzilius (host scientist)
Institute of Chemistry
Department of Physical Chemistry