We will cover the basics of protein dynamics and, in particular, flexibility in insoluble aggregates and its potential relevance in neurodegeneration and drug design strategies. We will pay special attention to NMR techniques in solution and solid-state that permit for quantification of the dynamics. Examples will include lineshape analysis, as well as more sophisticated methods such as rotating frame relaxation measurements, and saturation transfer techniques. We will briefly consider other methods, such as cryo electron microscopy and X-ray crystallography.
Contact:
Prof. Dr. Björn Corzilius (host scientist)
Institute of Chemistry
Department of Physical Chemistry
Dr.-Lorenz-Weg 2
18059 Rostock